Ajay Chawla, MD, PhD

Professor
Cardiovascular Research Institute
Department of Physiology
Department of Medicine
+1 415 857-3709

Across species, the aberrant activation of the innate immune system has been linked to pathogenesis of metabolic, inflammatory, and degenerative diseases.  However, the molecular pathways by which innate immune cells coordinate these diverse programs remain poorly understood.  Our major goals are to elucidate the regulatory role of nuclear receptors, co-activator proteins, and nutrient sensors in innate immune activation, and the importance of these pathways in regulation of systemic metabolism and tissue regeneration.

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Research Summary: 
Immune determinants of metabolism and regeneration
Publications: 

Myeloid Bmal1 deletion increases monocyte recruitment and worsens atherosclerosis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Huo M, Huang Y, Qu D, Zhang H, Wong WT, Chawla A, Huang Y, Tian XY

Immunity around the clock.

Science (New York, N.Y.)

Man K, Loudon A, Chawla A

Insulin Signaling in a Bit of a Jam.

Cell

Kutyavin VI, Chawla A

Type 2 responses at the interface between immunity and fat metabolism.

Current opinion in immunology

Odegaard JI, Chawla A

Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis.

Nature communications

Xue J, Sharma V, Hsieh MH, Chawla A, Murali R, Pandol SJ, Habtezion A