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BMS Courses
BMS 230: Molecular & Cellular Biology of Cancer
Winter 2009, 3.5 units

BMS 230 will be offered again in fall 2010.

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Schedule: Winter quarter 2009, January 5– March 20
Lectures: Monday and Tuesdays, 4:00 PM - 6:00 PM. 15 minute break and time for questions
Advanced Topics:
Thursdays 4:00 PM - 5:30 , Room U-506
Location: room N-729, Parnassus

Please pre-registister for this course: here

Advanced Topics Format: 30-40 minute lecture/discussion lead by a guest lecturer who will discuss an important topic/paradigm or an emerging and/or controversial issue/area related to CANCER.
40-minute journal club presented by one or two students (depending on enrollment) presenting article(s) relating to Lecture topic(s) that week. Students will identify a faculty mentor for assistance with their journal club, and that will attend their presentation.

Exam:
One question related to the course contents will be given to enrolled students. Relevant references for a series of articles pertaining to the content of the question will be provided. From the references, students will extract salient details and synthesize their responses in the form of a coherent and scholarly 3-5 page essay.

Course Objectives:
Lectures
will provide a broad understanding of the epidemiologic, molecular genetic, cell and pathobiological aspects of human cancer focusing on 1) regulatory and effector mechanisms and experiments demonstrating their functional significance in model systems and in human cancers, 2) the cells constituting tumor microenvironments and composing the tumor as an organ, and 3) relationships between basic biomedical research and their clinical applications.

In the Advanced Topics series, students will present concise literature reports supporting concepts discussed in the Lecture series, supported by a Faculty discussion leader who will pose an interesting and/or controversial spin on the topic. Together, these will enable students to engage in independent research projects using state-of-the-art methodology and model systems designed to improve our understanding of the etiology, diagnosis, prevention and treatment of cancer.

Re
commended textbook: The Biology of Cancer (2007) by Robert A. Weinberg

Except for the first lecture on 1/5, hard copies of lecture materials will not be provided. Please remember to download course materials prior to each class.

Final Exam

Course Evaluations

Date Topic Lecturer Lecture Materials
Monday 1/5 (4-6 PM) Cancer & Society Margaret Tempero Lecture
Tuesday 1/6 (4-6 PM) Cancer Causes & Epidemiology Bob Hiatt

Lecture
Paper 1
Paper 2
Paper 3

Advanced Topic: Thursday 1/8 (4-5:30 PM) Required Organizational Meeting for all Enrolled Students Lisa Coussens & Martin McMahon  
Monday 1/12 ( 4-6 PM) Cancer Pathogenesis (normal, chronic disease and cancer) Jay Debnath

Lecture
Kumar: Robbins and Cotran: Pathologic Basis of Disease. Pathologic Basis of Disease: Chapt. 7 - Neoplasia http://www.mdconsult.com/das/book/0/view/1249/60.html

Tuesday 1/13 (4-6 PM) Cancer Genetics & Chromosomes Boris Bastian Lecture
Advanced Topic: Thursday 1/15 (4-5:30 PM) Genetic Associations & Cancer Boris Bastian Lecture
Paper 1

Paper 2
Paper 3
Paper 4
Monday 1/19 HOLIDAY  
Tuesday 1/20 (4-6 PM) Signaling/Mechanisms 1: Martin McMahon Lecture
Advanced Topic: Thursday 1/22 (4-5:30 PM ) Room U-506 Immunotherapeutics and Cancer Vaccines (HC, HPV, prostate) Karen Smith McCune Lecture
Paper 1

Paper 2
Paper 3
Paper 4
Monday 1/26 (4-6 PM) Signaling/Mechanisms 2: Viruses and Cancer Martin McMahon Lecture
Tuesday 1/27 (4-6 PM) Signaling/Mechanisms 3: oncogenes & tumor suppressor genes Martin McMahon Lecture
Advanced Topic: Thursday 1/29 (12-1:30 PM) Special time & location: Room U-506 Parallels of Development and Cancer Zena Werb

Lecture
Paper 1
Paper 2
Paper 3
Paper 4
Paper 5

Monday 2/2 (4-6 PM) Cell Death Mechanisms Jay Debnath Lecture
Tuesday 2/3 (4-6 PM) Cancer Microenvironment Lisa Coussens Lecture
Advanced Topic: Thursday 2/5 (4-5:30 PM ) Room U-506 Metabolism and Cancer Gerard Evan

Lecture
Paper 1
Paper 2
Paper 3

Monday 2/9 (4-6 PM) Immune Cells & Cancer Lisa Coussens Lecture
Tuesday 2/10 (4-6 PM) Tumor Angiogenesis Gabriele Bergers Lecture
Paper 1

Paper 2
Paper 3
Paper 4
Advanced Topic: Thursday 2/12 (12-1:30 PM) Special time & location: Room U-506 Mouse models of human cancer Gerard Evan

Lecture
Paper 1
Paper 2
Paper 3

Monday 2/16 (4-6 PM) HOLIDAY  
Tuesday 2/17 (4-6 PM) Mechanisms of Invasion & Metastasis Gabriele Bergers Lecture
Paper 1

Paper 2
Paper 3
Paper 4
Advanced Topic: Thursday 2/19 (4-5:30 PM) Room U-506 Evidence that metastasis genes exist Martin McMahon

Lecture

papers covered:
Paper 1
Paper 2

additional reading:
Paper 3
Paper 4
Paper 5
Paper 6

Monday 2/23 (4-6 PM) Breast Cancer as archetypical solid tumor: pathogenesis, genetics, treatment and treatment failures, metastasis and stem cells Mark Moasser Lecture
Tuesday 2/24 (4-6 PM) CML as archetypical hematopoietic malignancy: pathogenesis, genetics, treatment and treatment failures, metastasis and stem cells Neil Shah Lecture
Advanced Topic: Thursday 2/26 (4-5:30 PM) Room U-506 How to generate a targeted therapeutic Jim Wells

Lecture
papers covered:
Paper 1
Paper 2

additional reading:
Paper 3
Paper 4
Paper 5
Paper 6
Paper 7

Monday 3/2 (4-6 PM) Conventional cancer R x Margaret Tempero Lecture
Tuesday 3/3 (4-6 PM) Cancer cell autonomous targeted R x Neil Shah Lecture
Advanced Topic: Thursday 3/5 (4-5:30 PM) Room U-506 “Grandiomics”: Genome-wide approaches to exploring the cancer genome Joe DeRisi Paper 1
Paper 2
Paper 3
Monday 3/9 (4-6 PM) Cancer cell non-autonomous targeted R x Doug Hanahan Lecture
Tuesday 3/10 (4-6 PM) Stem cells, Development & cancer Emmanuelle Passegue Lecture
Advanced Topic: Thursday 3/12 (4-5:30 PM) Room U-506 Cancer Medicine in 2020 Frank McCormick Lecture
Paper 1

Paper 2
Paper 3
Paper 4
3/16-20 Final Exam: take home essay due Friday March 20th 5:00 PM FINAL EXAM

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