Biomedical Sciences (BMS) Graduate Program
Admissions | Academic Program | Faculty | Events | Campuses & Facilities | The Bay Area | BMS Intranet | Students | Home
BMS Courses
BMS 211 Population Genetics and Molecular Evolution
Winter 2008, 3 units

Students and Postdocs are welcome to attend!

 

Instructor

Jeff Wall

Institute for Human Genetics

513 Parnassus Ave., S965

San Francisco, CA 94143

Phone: 415-476-4063

Email: wallj@humgen.ucsf.edu

 

Meeting time and Place

Dates/Times: Tuesday and Thursday, 2:30-4pm.

Location: S-980 (except on 1/22 and 2/26, when class will be held in HSW-920)  

 

Overview

This course will concentrate on understanding and interpreting patterns of DNA sequence variation both within species (population genetics) and between species (molecular evolution), with a focus on human evolutionary genetics.  With recent advances in molecular sequencing (and genotyping) technology, there is now a flood of genetic polymorphism data available.  Making sense of large-scale data sets is likely to be a key challenge for many years to come.

 

The course will have a mixture of lectures as well as round-table discussions of recent papers from the literature.  Additional lecture notes and review articles will also be provided, as well as suggestions for further reading.  Students will be graded based on occasional problem sets and class participation.

 

Prerequisites

A basic understanding of genetics is required.  Familiarity with calculus and statistics is preferable.

 

Downloadable course schedule


*******************************************************************************************************************
Course Evaluations Forms : General Course Evaluation / Instructor Evaluation Form

*Due:   March 13, 2008 . Submission of completed evaluation forms is a course requirement.  

*Please do not include your name.. Evaluations are confidential.

*You may either fill out the forms electronically or hard copy. If you fill out the forms electronically, underline numerical ratings, highlights will not show up clearly when xeroxing.

*Return completed evaluations to Monique Piazza, electronically, or Box 0452, HSE-1288, hard copy.

********************************************************************************************************************

Date Location Lecture Topic Downloads
Thurs., Jan. 3 HSW-654 Introduction and overview Lecture 1
Tue., Jan. 8 S-980 The Neutral Theory Lecture 2
Thur., Jan. 10 S-980 No class  
Tue., Jan. 15 S-980 Coalescent theory and basic probability Lecture 3
Thur., Jan. 17 S-980 Coalescent theory and basic probability Lecture 4
Tue., Jan. 22 HSW-930 Demography Lecture 5
Thur., Jan. 24 S-980 Demography Lecture 6
Tue., Jan. 29 S-980 Demography Lecture 7
Thur., Jan. 31 S-980 Recombination Lecture 8
Tue., Feb. 5 S-980 Recombination Lecture 9
Thur., Feb. 7 S-980 Linkage disequilibrium Lecture 10
Tue., Feb. 12 S-980 Linkage disequilibrium Lecture 11
Thur., Feb. 14 S-980 Linkage disequilibrium Meyers et al 2005
Tue., Feb. 19 S-980 Natural selection Lecture 12
Thur., Feb. 21 S-980 Natural selection Lecture 13
Tue., Feb. 26 HSW-930 Natural selection Voight et al. 2006
Thur., Feb. 28 S-980 Comparative genomics Lecture 14
Tue., Mar. 4 S-980 Comparative genomics Lecture 15
Thur., Mar. 6 S-980 Association mapping Pollard et al 2006a
Tue., Mar. 11 S-980 Association mapping  

© 2009-2010 The Regents of the University of California. All rights reserved.
Image Credits