Students and Postdocs are welcome to attend!
Instructor
Jeff Wall
Institute for Human Genetics
513 Parnassus Ave., S965
San Francisco, CA 94143
Phone: 415-476-4063
Email: wallj@humgen.ucsf.edu
Meeting time and Place
Dates/Times: Tuesday and Thursday, 2:30-4pm.
Location: S-980 (except on 1/22 and 2/26, when class will be held in HSW-920)
Overview
This course will concentrate on understanding and interpreting patterns of DNA sequence variation both within species (population genetics) and between species (molecular evolution), with a focus on human evolutionary genetics. With recent advances in molecular sequencing (and genotyping) technology, there is now a flood of genetic polymorphism data available. Making sense of large-scale data sets is likely to be a key challenge for many years to come.
The course will have a mixture of lectures as well as round-table discussions of recent papers from the literature. Additional lecture notes and review articles will also be provided, as well as suggestions for further reading. Students will be graded based on occasional problem sets and class participation.
Prerequisites
A basic understanding of genetics is required. Familiarity with calculus and statistics is preferable.
Downloadable course schedule
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Course Evaluations Forms : General Course Evaluation / Instructor Evaluation Form
*Due: March 13, 2008 . Submission of completed evaluation forms is a course requirement.
*Please do not include your name.. Evaluations are confidential.
*You may either fill out the forms electronically or hard copy. If you fill out the forms electronically, underline numerical ratings, highlights will not show up clearly when xeroxing.
*Return completed evaluations to Monique Piazza, electronically, or Box 0452, HSE-1288, hard copy.
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| Date |
Location |
Lecture Topic |
Downloads |
| Thurs., Jan. 3 |
HSW-654 |
Introduction and overview |
Lecture 1 |
| Tue., Jan. 8 |
S-980 |
The Neutral Theory |
Lecture 2 |
| Thur., Jan. 10 |
S-980 |
No class |
|
| Tue., Jan. 15 |
S-980 |
Coalescent theory and basic probability |
Lecture 3 |
| Thur., Jan. 17 |
S-980 |
Coalescent theory and basic probability |
Lecture 4 |
| Tue., Jan. 22 |
HSW-930 |
Demography |
Lecture 5 |
| Thur., Jan. 24 |
S-980 |
Demography |
Lecture 6 |
| Tue., Jan. 29 |
S-980 |
Demography |
Lecture 7 |
| Thur., Jan. 31 |
S-980 |
Recombination |
Lecture 8 |
| Tue., Feb. 5 |
S-980 |
Recombination |
Lecture 9 |
| Thur., Feb. 7 |
S-980 |
Linkage disequilibrium |
Lecture 10 |
| Tue., Feb. 12 |
S-980 |
Linkage disequilibrium |
Lecture 11 |
| Thur., Feb. 14 |
S-980 |
Linkage disequilibrium |
Meyers et al 2005 |
| Tue., Feb. 19 |
S-980 |
Natural selection |
Lecture 12 |
| Thur., Feb. 21 |
S-980 |
Natural selection |
Lecture 13 |
| Tue., Feb. 26 |
HSW-930 |
Natural selection |
Voight et al. 2006 |
| Thur., Feb. 28 |
S-980 |
Comparative genomics |
Lecture 14 |
| Tue., Mar. 4 |
S-980 |
Comparative genomics |
Lecture 15 |
| Thur., Mar. 6 |
S-980 |
Association mapping |
Pollard et al 2006a |
| Tue., Mar. 11 |
S-980 |
Association mapping |
|
|