BMS 270 Mini-Courses
BMS participates in a collaborative program with other UCSF graduate programs to offer a spring quarter curriculum designed around mini-courses formatted as intensive, round-table discussions of current literature on specific topics. The quarter is divided into three modules of two to three weeks each with programs offering several mini-courses choices per module. BMS mini-courses include translational, single disease or organ systems topics. Topics will change every year. Also, the idea is to take only one mini-course per module. All mini-courses are pass/fail.
First Year Students are required to take three mini-courses (one per module) as part of the core requirement, and two of the three must be chosen from the BMS mini-courses. MSTP students in BMS are required to complete three mini-courses to satisfy the core requirement, and these may chosen from either the BMS or PIBS lists.
Second year and above BMS students may take BMS or PIBS mini-courses or full-length courses to satisfy the elective requirement. Two mini-courses or one full-length course are required for PhD students, and two mini-courses or two full-length courses are required for MSTP students. Please note this is in addition to the core requirement outlined above.
While all mini-courses will be available to all students, first year students will be given first priority for courses offered by their home programs.
Please remember that if you are taking any BMS mini-course for credit, you will need to officially register by filing the course as BMS 270 (3 units) with the appropriate course director as the instructor on your study list (the Spring 2012 study list is not available yet).
GEMS COURSE: For BMS first-year students, if you get into the GEMS course (which for BMS students counts as 2 BMS mini-courses):
Option 1: You can take your third mini-course either module II OR module III.
Option 2: If you like, you can still take a mini-course in module II AND III.
Spring 2012 Mini-Courses Modules:
Module I: Monday, March 26- Friday, April 13, 2012
Module II: Monday, April 16 - Friday, May 4, 2012
Module III: Monday, May 7 - Friday, May 25, 2012
Click a Program Name to jump to listings
BMS
CCB
iPQB
GEMS
Neuroscience
PSPG
Tetrad
Spring 2012 BMS Mini-Course Topics:
BMS 270: Practical Bioinformatics without Programming
Course Directors: Mark Voorhies
Description: Through a series of lectures and exercises, students will learn core skills for analyzing large data sets and documenting their analysis. Exercises will focus on using interactive programs and web resources to analyze gene expression data. There will be no programming component, but the content will have significant overlap with the "Practical Bioinformatics with Programming" minicourse. Students will need a laptop.
Prereq:
Module: 1
Days/Times: Mar 26-Apr 6, M-F, 3-5pm
Location: Parnassus, HSW-654
BMS 270: Listeria and Yersinia: from classic studies to cutting edge bacterial pathogenesis
Course Directors: Joanne Engel
Description: Graduate level course using studentled discussion format where the students discuss one-two papers each meeting. We will start by reading some of the seminal papers in the field of microbial pathogenesis that utilized Yersinia and Listeria as "model" organisms and progress to more recent cutting edge biology papers. We will use these papers to understand how genetic approaches were applied to studying host-pathogen interactions, how they lead to the discovery of specialized protein export systems, how they defined specific bacterial host adhesion and entry mechanisms, and how they led to the discovery of how pathogens co-opt host cell processes, including the actin cytoskeleton, apoptosis, vesicular trafficking, and the innate immune response. At the first meeting, the class will decide which days of the week to meet to fulfill the requirement of 20 hrs of class time (the course is scheduled Monday thru Friday 3-5 pm for the entire 3 weeks, but we will only meet 10 times). Cell biology and genetics is a prerequisite.
Prereq: Cell biology and genetics
Module: 2
Days/Times: Apr 16-May 4, M, T, Th, F, 3-5pm
Location: Parnassus, N-527 & N-617
BMS 270: Practical Bioinformatics with Programming
Course Directors: Mark Voorhies
Description: Through a series of lectures and exercises, students will learn core skills for analyzing large data sets, documenting their analysis, and converting analysis protocols into reusable computer programs. Exercises will focus on using the Python programming language to analyze gene expression data, with an emphasis on concepts applicable to many programming languages and many areas of research. No prior programming experience is required. Students will need a laptop.
Prereq:
Module: 2
Days/Times: Apr 16-Apr 27, M-F, 3-5pm
Location: Parnassus, HSW-654 & HSE-532
BMS 270: Immunometabolism
Course Directors: Ajay Chawla, Rich Locksley, and Eric Verdin
Description: Immunology and Metabolism is a graduate level course in an open discussion format. Students will evaluate and discuss key papers highlighting the crosstalk between the immune and metabolic systems. Goals of this mini-course are to learn the experimental approaches being utilized to address the key questions in this field, and to gain appreciation for how these pathways contribute to pathogenesis of obesity and diabetes in humans.
Prereq:
Module: 2
Days/Times: Apr 16-May 4, 1-3pm
Location: Parnassus/Mission Bay, C-417/SC241
BMS 270: Principles and Implications of Oncogene Addiction
Course Directors: Martin McMahon, Scott Oakes, Ben Braun
Description: Participants in this course will conduct an in-depth and rigorous evaluation of the concept of "Oncogene Addiction" and the implications of this phenomenon to the treatment of patients with pathway-targeted cancer therapeutics. Papers to be discussed will span the history of oncogene research from the first description of temperature-sensitive forms of Rous Sarcoma Virus through the identification, validation and drug targeting of oncogenes directly relevant to human cancer. Specific disease and treatment paradigms to be discussed will include the use of pharmacological and antibody based anti-cancer therapeutics to target leukemia, breast cancer and melanoma.
Prereq:
Module: 3
Days/Times: May 7-May 24, M, W, Th, 4-6:15pm
Location: Mission Bay, HD-296
BMS 270/DSCB 270: Angiogenesis and Vascular Biology
Course Directors: Matt Springer
Description: This minicourse will focus on the different forms of blood vessel growth and function. Concepts to be explored in depth will include basic cellular and molecular mechanisms of angiogenesis and arteriogenesis (developmental biology that occurs even in the adult), sprouting angiogenesis vs. cell-based vasculogenesis (including the controversy of whether endothelial progenitor cells are actually endothelial progenitor cells), potential for angiogenic therapy and why it has been so slow to become a reality, tumor vasculature and issues of anti-angiogenesis, and endothelial vasodilatory function.
Prereq:
Module: 2
Days/Times: Apr 16-May 4, M, T, Th, F, 3-5pm
Location: Parnassus, S-170
BMS 270/DSCB 270: Epigenetics of Reprogramming and Disease
Course Directors: Robert Blelloch, Daniel Lim, Miguel Ramalho-Santos
Description: This course will cover latest topics in the role of epigenetics in normal development, reprogramming, and disease. Topics will include the role of DNA methylation, histone marks, chromatin remodeling and non-coding RNAs in cellular differentiation, reprogramming and disease. The course will involve the reading and discussion of recent select seminal papers in the field. The instructors will provide some background and then papers (1 per session) will discussed as a group.
Prereq:
Module: 3
Days/Times: May 8-May 25, T, Th, F, 2-4:15pm
Location: Parnassus, Stem cell boardroom
BMS 270/Biochem 210: Communicating in a Complex World
Course Directors: Suzanne Noble, Jeff Cox, Anita Sil
Description: Animals and plants associate with a coevolved set of microbial partners that are essential for health. Even in the simplest examples, these interactions involve highly intricate molecular "conversations" between host and symbiont. Furthermore, the recent development of deep-sequencing technologies has led to an explosion of studies on the fundamental instructive role of the much more complex mammalian microbiome and its role in gut development, immunity, and disease. This course will explore the mechanisms of the host-symbiont relationship using experimental examples that range from the study of "simple", genetically tractable model systems to that of the human gut flora.
Prereq: none, a genetics course is recommended
Module: 3
Days/Times: May 7-21, no class on May 18, 3-5pm
Location: Mission Bay, BH 215, Except 5/9 and 5/16 in BH 413
Spring 2012 CCB Mini-Course Topics:
Advanced Topics in Synthetic and Medicinal Chemistry
Course Directors: Jack Taunton, Adam Renslo
Description: This mini-course requires a strong background in synthetic organic chemistry, including knowledge of basic synthetic methods (e.g., Diels-Alder, Pd-catalyzed cross-coupling, aldol, oxidation/reduction, protecting groups, peptides) and reaction mechanisms (arrow pushing, basis of stereo- and regioselectivity). Knowledge of these areas at the level of an advanced undergraduate synthesis course is strongly preferred. In this mini-course, we will: (1) discuss classic and recent papers on the synthesis of complex molecules (e.g., natural products and advanced drug candidates), and (2) discuss problem sets involving the design of multi-step synthetic routes. Students will be required to present and analyze multi-step synthetic routes (based on assigned literature and problem sets) on the board at every class. Through the intensive study of multi-step synthesis, students will expand their knowledge base of synthetic methods and their ability to strategically design synthetic routes.
Prereq:
Module: 1
Days/Times: , M-F, 10-12pm
Location: Mission Bay, GH N114
Mass Spectrometry
Course Directors: Al Burlingame
Description: This course will cover the fundamentals and applications of capillary chromatography and mass spectrometry in protein identification and peptide sequence analysis. Current instrument designs, their analytical properties and relative merits will be discussed, methods for sample preparation and mass spectral data acquisition will be reviewed, and then methods and software tools for data analysis will be presented.
Prereq:
Module: 2
Days/Times: , T, Th, 10-12pm
Location: Mission Bay, GH N114
Genetically encoded imaging probes: mechanism, development and application
Course Directors: Xiaokun Shu
Description: This mini-course will focus on the genetically encoded probes for fluorescence and electron microscopy as well as small animal imaging, including: 1) Mechanism - biophysical basis of photo-physical properties including spectra, brightness; 2) Development - rational design and directed evolution; 3) Biological applications. We will also discuss the latest development and future directions.
Prereq:
Module: 2
Days/Times: , T, Th, 10-12pm
Location: Mission Bay, GH S261
Enzyme Kinetics
Course Directors: Sue Miller
Description: As the facilitators of the chemical reactions of living systems, enzymes are often important as tools or as direct subjects of study for "biomedical" scientists. The objective of this course is to use a combination of didactics and discussion of papers to illustrate approaches to the study and use of enzymes.
Prereq:
Module: 3
Days/Times: May 7, 8, 9, 11, 14, 16, 18, 21, 23, 25, 1-3pm
Location: Mission Bay, GH S261
Spring 2012 iPQB Mini-Course Topics:
Scientific Software Development
Course Directors: Tom Ferrin
Description: This course is an intensive introduction to basic software development practices for scientists and engineers. The goal is to provide scientists with the skills needed to create more reliable and maintainable programs while reducing the time spent on programming.
Prereq:
Module: 1
Days/Times: , M-F, 2-4pm
Location: Mission Bay, GH S261
Protein Crystallography
Course Directors: Robert Stroud
Description: A theoretical and practical course on the basis for understanding, and using protein crystallography, x-ray solution scattering, electron microscopy, and its products, depositions in the Protein Data Bank. The basis of scattering, and diffraction and recovery of the structural detail from scattered intensities and the basis for inverse transformation is accompanied by laboratory hands on experience in crystallizing your own, - or other protein, recording diffraction and calculating the maps that allow interpretation of structure. Cautions and experimental limitations, and recognition of problems, and the impact of accuracy on interpretation are illustrated with working examples. The lab section will allow full refinement of a structure and a group discussion of the quality of the resulting structures in the closing sessions. http://www.xtranormal.com/watch/11133654/so-you-want-to-be-a-protein-crystallographer
Prereq:
Module: 1
Days/Times: , M, W, Th, F, 9-11am
Location: Mission Bay, GH S536A (except 328- GH N426A)
Inference and imputation in evolutionary and human genetics
Course Directors: Jeff Wall
Description: An important component of modern genetics is the ability to make inferences about unknown parameters or to make educated guesses about missing data. This mini-course will focus on the computational and statistical methods used for inference and imputation in genetics (e.g., maximum likelihood, approximate Bayesian computation, Markov chain Monte Carlo, hidden Markov models), as well as the applications of these methods in human and evolutionary genetics (e.g., estimating demographic parameters, inferring haplotypic phase, genotype imputation).
Prereq:
Module: 1
Days/Times: Mar 26-April 6
Location: TBD
Cellular Cognitiion - exploring the computational power of individual cells
Course Directors: Wallace Marshall
Description: The cell is a complex machine whose full range of capabilities are still being discovered. The signaling networks within a cell can be viewed as computing circuits, raising the question of how much computational capacity a single cell might have. The answer to this question would have major implications in all aspects of biology, medicine, and bioengineering, but learning how much a cell can compute is a challenge because it requires us to combine molecular and cellular biology with approaches from psychology and computer science. In this course we will consider the extreme view that cells "think", and see how far we can push it. In this course we will read and discuss key papers that purport to document intelligent behavior of single cells, such as learning and maze-solving, as well as less controversial papers describing the information processing and computational properties of intracellular signaling networks. In conjunction with these papers, we will design and perform our own hands-on experiments to test some of the claims in the literature about behaviors of cells, which could potentially lay the ground-work for future mechanistic studies of these behaviors. This will be an intense course requiring active participation and an open mind, as well as a willingness to think about a wide range of approaches spanning biology, psychology, and engineering.
Prereq:
Module: 2
Days/Times: , M-F, 10-12pm & 2-4pm
Location: Mission Bay, GH S227 (teaching lab)
How do organisms, cells, and molecules organize themselves: distributed computation in biology
Course Directors: Matthew Thomson, David Soloveichik (Wendell Lim on study list)
Description: Biological systems often solve problems through distributed computations where individual agents (proteins, cells, organisms) collect information and dynamically interact to accomplish a task. Examples of distributed computation exist across scales of biological organization: the computation of cell morphology by the actin cytoskeleton; the selection of high affinity B-cell clones by the immune system; sensory integration in the brain; choice of flight direction in bird flocks. Even regulatory networks can be thought of as multi-agent systems, in which a set of molecules has to make a concerted decision. Computer science and statistical physics have developed rich theoretical tools for studying multi-agent systems and collective behaviors. This course will draw on this rich history, combining it with an analysis of specific biological examples, to discuss the development of a theory for distributed computation in biology. Topics may include: chemical reaction networks, cell polarity, immune system dynamics, Hopfield neural networks, and flocking. Theoretical investigation into distributed algorithms in biology might uncover common principles used across systems and common implementation challenges like the aggregation of noisy signals and decision making in groups.
Prereq:
Module: 2
Days/Times: , M-Th, 2-4pm
Location: Mission Bay, GH S261
Statistical Methods of Array and Sequence Data
Course Directors: Mark Segal
Description: This course aims at detailing statistical methods and issues arising in the analysis of high dimensional, molecular biological data, with an emphasis on array platforms and sequence. Using a case studies approach, a range of statistical techniques that are frequently encountered in genomics settings are illustrated and evaluated. A lab provides introduction to the open source, widely used, and highly flexible statistical programming language, R, and the companion Bioconductor suite of bioinformatics packages developed for genomic analysis.
Prereq:
Module: 3
Days/Times: TBD
Location: Mission Bay, GH N114
Quantum Mechanics
Course Directors: Matt Jacobson
Description: Basic concepts and methods of quantum mechanics, and their roles in studying biomolecules. Combination of lectures, problem sets, and discussions. Emphasis on electronic structure theory. Prior experience with quantum mechanics is helpful but not 100% necessary. The approach I take emphasizes intuitive understanding rather than detailed derivations, but a certain comfort-level with mathematics is nonetheless important.
Prereq:
Module: 3
Days/Times: May 7-May 18, M-F, 10-12pm
Location: Mission Bay, GH S261
Cellular Cognitiion - exploring the computational power of individual cells
Course Directors: Wallace Marshall
Description: The cell is a complex machine whose full range of capabilities are still being discovered. The signaling networks within a cell can be viewed as computing circuits, raising the question of how much computational capacity a single cell might have. The answer to this question would have major implications in all aspects of biology, medicine, and bioengineering, but learning how much a cell can compute is a challenge because it requires us to combine molecular and cellular biology with approaches from psychology and computer science. In this course we will consider the extreme view that cells "think", and see how far we can push it. In this course we will read and discuss key papers that purport to document intelligent behavior of single cells, such as learning and maze-solving, as well as less controversial papers describing the information processing and computational properties of intracellular signaling networks. In conjunction with these papers, we will design and perform our own hands-on experiments to test some of the claims in the literature about behaviors of cells, which could potentially lay the ground-work for future mechanistic studies of these behaviors. This will be an intense course requiring active participation and an open mind, as well as a willingness to think about a wide range of approaches spanning biology, psychology, and engineering.
Prereq:
Module: 2
Days/Times: Apr 16-May 4, M-F, 10-12pm & 2-4pm
Location: Mission Bay, GH 227
Spring 2012 GEMS Mini-Course Topics:
NS 219: GEMS: Introduction to Human Biology and Medicine
Course Directors: Andrew Leavitt
Description: This minicourse is designed to introduce graduate students in the life sciences to normal human tissue and organ biology, and to its dysregulation in disease. While we cannot make you fluent in the language of clinical medicine, our goal is to provide a working vocabulary centered on the rudiments of human anatomy and physiology, and to illustrate how this knowledge, when integrated with molecular studies, can illuminate disease pathogenesis and treatment. Armed with this knowledge, you will be better positioned to connect your basic science research to clinical problems in need of solutions. At a minimum, we hope that this course implants in you a desire to always ask, “how might my work be applied to advance human health?”
The course begins with an examination of human blood as a tissue, including a detailed consideration of hematopoiesis. We then look at its derangement in leukemia and myeloproliferative neoplasms, and look at hematopoietic stem cell transplants as an example of stem cell biology in the clinic. We will also discuss congenital and acquired problems of bleeding and clotting (thrombosis), in terms of the human diseases, underlying pathobiology the role and shortcomings of clinical tests, and the pros and cons of the current pharmaceutical armamentarium available to treat these disorders.
The course also includes an overview of the circulatory system and its regulation, including the basics of heart, the pulmonary and renal systems, and an overview of energy metabolism, including its neural and endocrine regulation, and its derangement in diabetes, obesity and cancer. New this year will be: (i) topics on neuroanatamy and physiology and two specific clinical problems – seizures and multiple sclerosis; (ii) biology of the liver and biliary system, linked to a discussion of common liver problems and their treatments, both medical and surgical.
Each topic will include lectures that provide basic and clinical information. To the extent possible, the course will also include more clinical sessions in which clinicians will present/interview patients or provide clinical vignettes that illuminate the natural history, epidemiology and treatment of selected disorders. Selected recent papers dealing with the molecular pathogenesis of some disorder may be presented and discussed, time permitting.
Prereq:
Module: 1
Days/Times: Mar 26-Apr 13, M-F,
Location: Parnassus, S-172, S-176, U-458, U-460 and Toland Hall.
Spring 2012 Neuroscience Mini-Course Topics:
NS 219: Topics in Basic or Translational Neuroscience: Interneuron Development
Course Directors: Sam Pleasure, John Rubenstein
Description: We will cover current mechanisms that govern the pre- and postnatal development of telencephalic interneurons, with a focus on cortical interneurons.
Prereq: NS Core Course
Module: 2
Days/Times: 4/16, 4/19, 4/23, 4/26, 4/30, 5/3, M, Th, 9-11am
Location: Mission Bay, RH-302
NS 219: Topics in Basic or Translational Neuroscience: Neuroinflammation
Course Directors: Susanna Rosi, Li Gan
Description: Neuroinflammation begins as a host defense mechanism associated with neutralization of an insult and restoration of normal structure and function, similar to inflammation in peripheral organs. However, if neuroinflammation is not regulated, it can result in a self-propagating and deleterious process. Neuroinflammation is an important element common to many neurological conditions associated with cognitive dysfunctions. At the end of this course, students should have an up-to-date, fundamental understanding of neuroinflammation and its relevance to neurological disorders. This class will meet three times a week for 2-3 hours each day to have in depth discussions on current research papers (normally 1-2 papers per class) that are of relevance for the course topic. There will be a total of 9 classes.
Prereq: none
Module: 3
Days/Times: 5/7, 5/9, 5/11, 5/14, 5/16, 5/18, 5/21, 5/23, 5/25, M,W,F, 9-11am
Location: Mission Bay, Rock Hall Auditorium, N114 and S204
Spring 2012 PSPG Mini-Course Topics:
PG 219 Pharmacokinetics in Drug Development
Course Directors: Leslie Benet, Kathy Giacomini and Deanna Kroetz
Description: Identifying candidate drugs with optimal absorption, distribution, metabolism and excretion properties (ADME) is a critical step in the development of new drugs. These properties are important determinants of whether a pharmacologically potent molecule will eventually become a therapeutic drug. This course will focus primarily on pharmacokinetics, which can be simply defined as what the body does to the drug. Pharmacokinetics describes the temporal relationship of drug concentrations in the body following administration to healthy subjects and diseased patients and is an essential consideration of all drugs under development before they can be approved by regulatory agencies. This course is intended for students interested in drug development. The course focuses on the basic principles of pharmacokinetics and the characteristics of a potential drug candidate that are essential for effective use in humans. Computational skills and modeling and simulation of pharmacokinetics are emphasized along with biological principles. The concepts will be taught through a series of lectures that are tightly linked with problem-based workshops.
Prereq: None
Module: 2
Days/Times: Apr 16-May 4, M-F, 9-12pm
Location: Mission Bay, TBA
PG 219/AKA PSPG 245C Principles of Pharmacogenomics
Course Directors: Nadav Ahituv
Description: This objectives of this course will be to understand genetic factors underlying efficacy/toxicity of drug therapy; to assess the value of phenotyping/genotyping in guiding drug therapy of individual patients; to evaluate genomic methods in drug design, development, and therapy.
Prereq: None
Module: 3
Days/Times: May 7-May 25, M-F, 9-12pm
Location: Parnassus, S-174
Spring 2012 Tetrad Mini-Course Topics:
Understanding the Basis of Monoallelic Expression
Course Directors: Barbara Panning, Stavros Lomvardas
Description: Although mammals are diploid and express both copies of most genes, there are important exceptions to this generality. Nearly 15% of mammalian genes are expressed from only one of two alleles. X-linked genes in females, and odorant receptor, immunoglobulin, T-cell receptor, interleukin, natural killer-cell receptor, and pheromone receptor genes all exhibit random, monoallelic expression, in which each cell randomly selects one allele as the expressed copy. This indicates that cells have the ability to treat identical sequences within the same nucleus differently. In this minicourse we will discuss recent findings that provide clues about the molecular mechanisms that underlie random, monoallelic expression.
Prereq: graduate genetics course
Module: 2
Days/Times: Apr 16-Apr 27, M-F, 10-12pm
Location: Mission Bay, BH 215
Selfish DNA as a Driver of Evolutionary Innovation
Course Directors: Hiten Madhani, Pat O'Farrell
Description: This intensive minicourse will explore the notion that selfish DNA elements, such as transposons, shape eukaryotic evolution in important ways and that their interaction genome defense systems, such as the small RNA systems, plays a key role in this process. We will select a group of related papers illustrating these principles and delving into the mechanisms of operation of the PIWI system of small RNA defense against transposons. Students will be required to critically analyze the literature and present their analysis to the group. The course will be meet for 2-4 hours/day for two weeks.
Prereq: interest and energy
Module: 2
Days/Times: Apr 16-Apr 27, M-F, 9:30-1:30pm
Location: Mission Bay, RH 218B
Modern Approaches to Studying Human Evolution
Course Directors: Sandy Johnson, David Morgan
Description: We recently celebrated the 200th anniversary of Darwin's birth and the 150th anniversary of the publication of "On the Origin of Species," it seems an especially appropriate time to consider how cells evolve. We will begin with selections from Darwin but will focus on a series of recent papers examining molecular mechanisms of evolution. We will discuss the contention that "nothing in biology makes sense except in the light of evolution" by considering specific examples where evolutionary studies have provided insight into the workings of modern cells. Topics will include how gene duplication and divergence work, how changes in gene regulation can provide evolutionary novelty ('evo-devo'), how the re creation and study of extinct molecules in the lab can be used to test specific hypotheses, and how genome-wide studies have deepened our understanding of evolution.
Prereq: Basic knowledge of molecular biology and genetics
Module: 3
Days/Times: May 7-11, May 21-25, M-F, 2-4pm
Location: Mission Bay, GH S201
The genetics and cell biology of aging and exceptional longevity
Course Directors: Cynthia Kenyon, Liz Blackburn
Description: What sets the rate and quality of aging? This minicourse course will explore the biology of aging in model organisms and humans, and the basis of current ideas on the causes of aging and longevity. The course will focus on several major themes and their potential interactions. We will discuss hormonal, nutrient and stress-sensing pathways that have been shown genetically (or even epigenetically, across generations) to extend lifespan in animals and, in some cases, possibly in humans as well. We will also explore genetic and non-genetic influences on the factors that determine self-renewal of cells including genomic wear and tear and telomere maintenance. We will ask how much biology is destiny (genetic influences) and conversely, how much other, non-genetic, factors can influence aging in humans. The course will consist of student-led discussions centered around key papers, interspersed with faculty-led presentations on the major themes that will help orient the discussions.
Prereq: A genetics course; undergraduate is sufficient
Module: 3
Days/Times: May 14-May 25, M-F, 2-5pm
Location: Mission Bay, GH S204
ER Quality Control
Course Directors: Peter Walter, Jonathan Weissman
Description: The course will cover cellular mechanisms that ensure quality of protein folding in the endoplasmic reticulum. We will cover protein targeting and translocation, the actions of molecular chaperons, ERAD, the UPR and ER to Golgi transport. We will read and discuss impacting papers in the recent literature.
Prereq: Cell bio 245 or equivalent
Module: 3
Days/Times: May 9-May 23, 1-5pm
Location: Mission Bay, GH S202