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(previous five years)

Student PI Year Graduated Dissertation Title
Brittany Anderton Goga 2015 Reprogramming of Glutamate Metabolism and Redox Homeostasis in De Novo MYC-Driven Liver Tumors
Dale Ando Finkbeiner 2015 Automated, High-throughput Analysis of Neurite Dynamics in Neurodegenerative Disease
Siang Yun Ang Bruneau 2015 An essential role for H3K4 methyltransferase KMT2D in heart development
Robert Bell Costello 2015 Discovery and molecular mechanism of cis-regulatory element mutations in cancer
Samantha Bell Cox 2015 Cytosolic detection of the vacuolar pathogen, Mycobacterium tuberculosis
Miranda Broz Krummel 2015 The Critical Role of CD103+ Dendritic Cells in Anti-Tumor T Cell Immunity
Ryan Delgado Lim 2015 Chromatin-modifying factor Mll1 maintains neural stem cell regional identity in the postnatal mouse brain
Sky Feuer Rinaudo 2015 Sexually dimorphic effects of in vitro fertilization (IVF) on offspring growth and metabolism: a mouse model
Anna Gillespie Huang, Y 2015 Characterizing APOE4-Induced Hippocampal Network Deficits in Mice
Yuyuan Han Cyster 2015 Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment
Robert Hesse Pomerantz 2015 The Duality of ARF: Enhanced Tumor Suppression at the Expense of Cellular Plasticity and Regenerative Ability
Gorjan Hrustanovic Bivona 2015 The Molecular Pathogenesis of EML4-ALK Driven Lung Cancer and Strategies to Overcome Clinical Resistance to ALK Inhibitors
Candia Kenific Debnath 2015 Regulation of metastatic phenotypes by autophagy
Taylor LaFlam Anderson 2015 The cis-Regulation of Aire Expression
Florie Mar Stohr 2015 Autophagy-Independent Senescence and Genome Instability  Driven by Targeted Telomere Dysfunction
Cameron Pitt McCormick 2015 Targeting Ras in Cancer: Mutation-Specific Dependencies in Oncogenic Signaling
Irina Proekt DeFranco 2015 Organ-Specific Autoimmunity Resulting from Combined Defects in Two Tolerance Checkpoints
Renee Rivas Srivastava 2015 Genomic and Cellular Analysis of a GATA4 Mutation in Human iPS Cell-derived Cardiomyocytes
Laura Simpson Ansel 2015 MicroRNA regulation of Th2 cell function and asthma pathogenesis
Kasia Skrzypczynska Weiss, A. 2015  
Yunshuo Tang Alvarez-Buylla 2015 Role of MGE- and CGE-derived Interneuron Subtypes in Transplant-induced Cortical Plasticity
Elisabeth Unger Shah, Nirao 2015 The role of aromatase in sexually dimorphic behaviors
Ivan Vujkovic-Cvijin McCune 2015 Effects of the gut-resident bacterial microbiome on host immune function during HIV/SIV disease
Eric Wang Oakes 2015 The Role of Apoptosis in Differentiation and Disease
Alison Coady Sil 2014 MyD88-dependent signaling and the host response to the human fungal pathogen Histoplasma capsulatum
Nicole Galloway Greene 2014 Cell-to-cell transmission of HIV-1 is required to trigger pyroptotic death of CD4 T cells in lymphoid tissue
Alexandra Greer Shin 2014 Human dendritic cells accumulate in lung disease and contribute to serum IgE clearance via FcERI
Yaohui Huang Balmain 2014 The Roles of the Lrig1- and Lgr6-Positive Stem Cells in the Skin and the Functions of the Molecular Markers That Define Them
Imran Khan Anderson 2014 Therapeutic Manipulation of Central T cell Tolerance
Fong Ming Koh Ramalho-Santos 2014 Chd1 is essential for the emergence of definitive hematopoietic stem and progenitor cells
Elisabeth Krow-Lucal McCune 2014 Distinct functional programming in human fetal and adult monocytes
Jasmine Lau Weiss, W 2014 Radiation induces a STAT3-dependent proneural-to-mesenchymal transition
Linda Lee DeFranco 2014 Mechanisms by which two different Toll-like receptor ligands induce divergent immune responses in the lungs
Alexander Mohapatra Locksley 2014 IL-33 and TSLP in chitin-induced lung inflammation
Erin Oswald Krummel 2014  
Debbie Ruelas Green 2014 The role of MicroRNAs in HIV-1 latency
Leslie Tong Huang, Y 2014 Roles of Apolipoprotein E and GABAergic Interneurons in the Pathogenesis of Alzheimer's Disease
Morgan Truitt Ruggero 2014 New Paradigms for eIF4E in Translating the Genome of Normal and Cancer Cells
Kurt Weiberth Finkbeiner 2014  
Jennifer Bando Locksley 2014 Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine
Hengameh Zahed Kargaran Finkbeiner 2014 A role for cytoskeletal proteins as modifiers of mutant Huntingtin toxicity
Pankai Sahai Nystul 2014 The follicle stem cells require a dynamic population of stromal cells in the Drosophila ovary
Robyn Mills Hermiston 2014 Cellular and molecular contributions of tlr9 to autoreactive b cells in a murine model of systemic lupus erythematosus
Justin Chen Weiss, W   The Genetics of Splicing in Neuroblastoma
Leonard Chavez Verdin 2014 Investigating the role of T cell activation on the establishment of HIV-1 latency in primary CD4+ T cells using a dual-reporter virus 
Marta Wegorzewska MacKenzie 2014 Maternal Immune Recognition of the Semi-Allogeneic Fetus During Fetal Intervention in Mice
Megan Salt McCormick 2014 Epithelial to mesenchymal transition rewires the mechanisms of proliferation and survival
Nir Oksenberg Ahituv 2014 The Function and Regulation of AUTS2
Lyndsay Murrow Debnath 2014 Atg12-Atg3 interacts with Alix to promote basal autophagic flux and late endosome function
Brett Johnson Costello 2014 Genetic divergence and therapy-driven evolution between initial and recurrent glioma
Elisabeth Krow-Lucal Engel 2014 Distinct functional programming in human fetal and adult monocytes
Joshua Faguet Cheyette 2014 Neuroendocrine Circuits governing C. elegans decision-making
Alexander Ramos Weiss, A 2014 The role of noncoding RNAs in neurogenesis
Gabriel Reyes Abbas 2014 Genetic Determinants of Disease Persistence and Overt Off-Target Resistance to TKI Therapy in Chronic Myeloid Leukemia
Carlos Rojo Seilestad 2014 Elucidating the Genetics of Vaccine-Induced Febrile Seizure Through a GWAS and Exome Sequencing
Michael Sachs Ramalho-Santos 2013 Epigenetic Regulation of Transcription and Cellular Potency during Mammalian Development
Any Heidersbach Srivastava 2013 The Role of microRNA-1 in the Mammalian Heart
Julie VanderMeer Ahituv 2013 Cis-regulatory elements in limb development and human congenital malformations
Francesca Gazzaniga Blackburn 2013 Non-canonical roles for telomerase in T cells and breast cancer cells
Adrian Barker Coughlin 2013 Protease-activated receptor-2 (PAR2) in epithelial biology
Alexandra Greer Shin 2013 Human dendritic cells accumulate in lung disease and contribute to serum IgE clearance via FcERI
Todd Metzger Anderson 2013 Control of Central and Peripheral Tolerance by Aire
Ashley Mahne Tang 2013 Dissecting immune regulation and dysregulation in autoimmune diabetes from the vantage point of the target tissue
Ying Xim Tan Weiss, A 2013 The role of Csk in the dynamic negative regulation of T cell receptor signaling
Kathryn Blaschke Ramalho-Santos 2013 Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in embryonic stem cells
Kegan Donlan Shannon 2013 Response and Resistance to Targeted Inhibitors in T-Lineage Leukemias
David Staudt (MSTP) Stainier 2013 Live Imaging of Myocardial Development in the Zebrafish
Albert Lee (MSTP) Ma 2013 Otubain 1 in T cell homeostasis and programmed cell death
Arif Hussain Saleem (MSTP) Coughlin 2013 The Role of Zebrafish Adhesion GPCR Eltd1 in Left-Right Asymmetry and Cardiovascular Development
Matthew Wheeler DeFranco 2013 Fine-tuning B cell antigen receptor signaling by reactive oxygen species and diacylglycerol metabolism
Timothy Schmidt (MSTP) Cyster 2013 CXCR4 Promotes B Cell Egress from Peyer's Patches
Brian Webster Greene 2013 Elucidating the Nature of Viral Competition in Hepatitis C Virus Infection
Michael Patnode Rosen 2013 Carbohydrate Binding Receptors in Leukocyte Migration and Activation
Ian Kratter (MSTP) Finkbeiner 2013 Serine 421 is a Crucial Mediator of Pathology in a Mouse Model of Huntington's Disease
Noelle Huskey Mullin Goga 2013 Targeting Cyclin Dependent Kinases in Embryonic Stem Cells and Cancer
Alex Greninger (MSTP) DeRisi 2013 Genomics and Proteomics of Picornaviruses
Jonathan Russell (MSTP) Ptacek 2013 Familial Cortical Myoclonus Caused by Mutation in NOL3
Lionel Lim Goga 2013 Understanding the Potential of MicroRNAs as Novel Therapeutic Targets in Cancer
Chris Nelson DeRisi 2012 Regulation of transcription in pathogens, yeast and people
Lauren Herl Martens Farese 2012 The Role of Progranulin in CNS Injury and Disease
Yelena Bronevetsky Ansel 2012 Investigation into the mechanisms underlying activation-induced microRNA and Argonautc downrcgulation in helper T cells
Jon Clingan Matloubian 2012 The Role of Innate Immune Recognition in Chronic Viral Infection
Annie Arguello Cheyette 2012 Dactl cooperates with Dishevelled-1 and Disrupted in Schizophrenia-1 during postsynaptic development in mouse forebrain GABAergic interneurons
Michelle Toft Graham Lowell 2012 Constitutive Syk Activity Deregulates Cell Signaling and Hematopoiesis
Melissa Ehlers Stewart Black 2012 NFATc1 controls skeletal muscle fiber type and is a negative regulator of MyoD transcriptional activity
Angela Sia Muchowski 2012 Mechanisms of Amyloid-beta Toxicity in the Yeast Saccharomyces cerevisiae
Sarah Gierke Wittmann 2012 Function and dynamics of microtubules and plus-end-tracking proteins during 3d epithelial remodeling
Mark White Srivastava 2012 The Role of NOTCH1 Signaling in Aortic Valve Calcification
Robert Judson Blelloch 2012 MicroRNAs Promote Induced Pluripotency Through the Regulation of Cooperative Gene Networks
Jane Yu Schneider 2012 On Generation of Variation in Craniofacial Development and Evolution
Elizabeth Gray Cyster 2012 Development and function of IL-17-committed gdT cells
Renee VanderLaan Hebrok 2012 Regulation of the development of pancreatic diseases by cell intrinsic and stromal influences
Kyriacos Koupparis McKerrow 2012 Investigating the function of CLK1 kinase in Trypanosoma brucei and identifying other essential kinases
Sachi Jain Yim Huang, Y 2012 Investigating the Effects of ADP-Ribosylation Factor (ARF) 4 on Pattern Separation and Dendritic Spine Development in Mice
Josie Clowney Lomvardas 2012 Genomic and nuclear organization of olfactory receptors
Jonathan Chou (MSTP) Werb 2012 Insights into breast cancer metastasis: understanding the roles of transcription factors, microRNAs and the tumor microenvironment
Renatta Knox (MSTP) Ferriero 2012 Fyn in Neonatal Hypoxic-Ischemic Brain Injury
Raymond Ng Willenbring 2012 A microRNA-21 surge facilitates rapid cyclin D1 translation and cell cycle progression in mouse liver regeneration
Karen Ring Huang, Y 2012 Direct Reprogramming of Mouse and Human Fibroblasts into Multipotent Neural Stem Cells with a Single Factor
Jeff Alexander Bruneau 2012 Stage-specific Chromatin Modification and Regulation in Cardiomyocyte Differentiation
Emily Harrington (MSTP) Rowitch 2012 Manipulating developmental mechanisms to promote remyelination
Feng-Yen Li (MSTP) Lenardo 2012 XMEN disease reveals novel regulatory roles for magnesium in the immune system
Danielle Shin (MSTP) Braun 2012 Biochemical Dissection of SHP-2 and C-CBL in Juvenile Myelomonocytic Leukemia
Amy Moon Wynshaw-Boris 2012 Molecular Genetics of Lissencephaly and Functions of LIS1 in Cell Division
Molly Thomas (MSTP) Ansel 2012 Eri1 Regulation of Lymphocyte MicroRNA Homeostasis and Effector Functions
David Steiner (MSTP) Ansel 2012 MicroRNA Regulation of Helper T Cell Cytokine Production and Differentiation
Ben Freeze (MSTP) Kreitzer 2012 Optogenetic Dissection of Pathway-Specific Processing in the Basal Ganglia
Emily Elliott Lowell 2012 Neutrophils as the Key Mediators of Antibody-induced Arthritis and Edema: The Central Role of Syk
Nicole Santos Reiter 2012 Primary cilia mediate vertebrate Hedgehog signaling through the regulation of Smoothened and Gli2
Emily Thornton Krummel 2012 Lung Surveillance Revealed by Two-Photon Live Imaging
Julie Hunkapiller Reiter 2011 The Role of Cilia and Polycomb-like 3 in Embryonic Stem Cell Maintenance and Differentiation
William Schachterle Black 2011 Transcriptional regulation of Gata4 in the developing heart
April Price Locksley 2011 Reporter mice reveal unexpected sources of effector cytokines
Emily Gogol Gross 2011 Discovery and Relevance of the Cell Envelope Stress Response sRNA Network in E.coli
Helen Hwang Rulifson 2011 Serial specification during Drosophila placodal neurogenesis
Rebecca Lock Debnath 2011 Novel functions for autophagy during Ras transformation
John Morris Hebrok 2011 Rewired pancreatic plasticity and the specification of pancreatic ductal adenocarcinoma precursors
Varvara Zeldovich Bakardjiev 2011 Placental Defenses against Infection
Kristen Coakley Roose 2011 Regulation of RasGRP1 protein in thymocyte development and peripheral T cells
Kathryn Austgen Oakes/Ganem 2011 Dissecting the ER stress-induced Apoptotic Pathway
You Bin Lin Brückner 2011

Characterization of regulators of blood cell number identified in a Drosophila genome-wide RNAi screen

Yun Choi McManus 2011 On RNA 3’-end Oligouridylation
Jana Broadhurst (MSTP) McCune 2011 Beyond the hygiene hypothesis: exploring the immunology of helminthic therapy
Amy Young McCormick 2011 Regulation of mitogen-activated protein kinase and phosphoinositide 3-kinase signaling by wild-type and oncogenic Ras
Alana Lerner Papa 2011 Investigation of apoptosis under endoplasmic reticulum stress during diabetes pathogenesis
Lisa Kelly Cyster 2011 EBI2 positions naïve and activated B cells
Bethann Hromatka Fisher 2011 Investigations into the human placenta:  sticky malaria and sweet sugars
Jesse Green Cyster 2011 The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement
Corey Miller (MSTP) McCune 2011 The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement
Jan Lui Kriegstein 2011 Developmental expansion of the human neocortex
Joyce Hu Matloubian 2011 Chemokine receptor CXCR3 affects the balance between effector and memory CD8 T-cell generation
Yvan Chanthery Weiss, W 2011 Paracrine signaling through MYCN enhances tumor-vascular interactions in neuroblastoma
Armando Lemus (MSTP) Engel 2011 Identification of Pseudomonas aeruginosa ExoT amino acid residues necessary for its proteasomal dependent degradation in the host cytoplasm
Landys Lopez-Quezada McKerrow 2011 Function of Macromolecular Serine Protease Inhibitors in the Human Blood Fluke Schistosoma mansoni
Wanda Kwan Muchowski 2011 Investigating the Role of Microglia and the Immune System in Huntington's Disease
Nga Bien-Ly Huang, Y 2011

Investigating the Effect of C-Terminal Truncated Apolipoprotein E4 on Amyloid-Beta-Induced Neuronal and Behavioral Deficits in Mice

Shuyi Zhang McKerrow 2011 Characterization of the host macrophage response to intracellular protozoan pathogens
Mary Mohrin Passegue 2011 DNA damage response and DNA repair during hematopoietic differentiation and development
Lilliana Radoshevich Debnath 2011 ATG12 Conjugation to ATG3 Modulates Mitochondrial Homeostasis and Cell Death
Nichole Reyes Oakes 2011 The Role of the Mitochondrial Apoptotic Pathway in Neuronal Development and Survival
Daniel Garcia Evan 2011 Using switchable mouse models to assess the therapeutic potential of MdmX and E2F3
Julia Gilden Krummel 2011

Control of the T Cell Cortex by the Septin Cytoskeleton

Steve Chmura Killeen 2011 In Vivo Genetic Fate Mapping of T-cell Receptor Signal Strength
Nathan Hunkapiller Fisher 2011 Human Trophoblast Differentiation and Invasion During Normal Pregnancy and Preeclampsia
Jaime Lopez Toczyski 2011 Damage-dependent Regulation of DNA Replication
Abigail Miller McCormick 2011 A novel role for a complex of PDZ proteins in PI3K signaling
Jesse Lyons McCormick 2011 Investigating the role of MC1R and cAMP signaling in melanoma
Shan-Shan Zhang Bruneau 2010 Connexin the dots in the His-Purkinje system: uncovering Irx3 function in cardiac conduction
Cristina Penaranda Bluestone 2010 Therapeutic interventions to modulate the anti-islet response in autoimmune diabetes
Courtney Anderson Black 2010 The role of the transcription factor MEF2C in cardiac and skeletal muscle metabolism
Elizabeth Theusch Gitschier 2010 The genetic epidemiology of absolute pitch
Sue-Ann Lee Muchowski 2010 Implication of the endosomal trafficking pathway in alpha-synuclein pathogenesis
Christopher Hackett Weiss, W 2010 Deciphering neuroblastoma development with classical genetics, exon arrays, and transposon mutagenesis
Collin Melton Blelloch 2010 Opposing microRNAs regulate mouse embryonic stem cell self-renewal
Marine Champsaur Lanier 2010 Effects of NKG2D ligand expression on host immune responses
Brigitte Watkins (MSTP) Brown 2010 Modulation of Host Inflammatory Responses by SecA2 of Mycobacterium marinum
Jonathan Esensten (MSTP) Bluestone 2010 Transcription factors in CD4+ T cell activation and differentiation
Marcus Zachariah (MSTP) Cyster 2010 T cell egress from the thymus via corticomedullary blood vessels
Rachel Jacks Diamond 2010 Tau Fibrils Enter Cells By Macroendocytosis
Janet Lau Hebrok 2010 Hedgehog signaling during pancreas development
Davina Wu (MSTP) Locksley 2010 Type 2 Cytokines in Adipose Tissue and Metabolic Regulation
Kate Stewart Weaver 2010 The Role of SWI/SNF Chromatin Remodeling in the Regulation of Stromal-Epithelial Interactions in Breast Tumorigenesis
Patrick Murphy Wang 2010 Notch Signaling in Brain Angiogenesis: Mechanisms of Arterial Venous Specification and Arteriovenous Malformation
Suzanne Angeli Diamond 2010 Identification and Characterization of Actin-Binding Motifs on the Androgen Receptor and Huntingtin: Implications for Polyglutamine Disease
Pooja Agarwal Black 2009 The Transcription Factor MEF2C Is Required For Craniofacial and Melanocyte Development
Ryan Swenerton  McKerrow 2009 Biochemical and Functional Characterization of Serine Proteases in Leishmania
Vanessa Angeles Reijo Pera 2009 Characterization of NANOS Expression and Function in Human Germ Cells
Jessica Van Ziffle  Lowell 2009 Neutrophils require Syk kinase to mount an effective host response to bacterial infection
Cory Nicholas Reijo Pera 2009 Embryonic stem cell-derived oocyte development in follicles by transplantation into an endogenous ovarian niche
Rebecca Botelho McCune 2009 Plasmacytoid dendritic cell function in pathogenic vs. non-pathogenic HIV and SIV infection
Kelly Haston Reijo Pera 2009 The Role of Dazl in Maintenance of Pluripotency and Murine Germ Cell Development in vivo and in vitro.
Cathy Collins (MSTP) Brown 2009 Host Ubiquitination of Cytosolic Mycobacteria
Trinna Cuellar McManus 2009 The Role of Dicer in Post-mitotic Dopaminoceptive Neurons and Turnover of Dicer Generated MiRNAs
Bess Frost Diamond 2009 Prion-Like Characteristics of the Microtubule-Associated Protein Tau
Cynthia Mysinger McCormick 2009 CAR is Not Required for Adenovirus Infection: Integrin alpha v beta 5 Mediates Binding to CAR-Negative Cells
Elizabeth Sharp Nixon 2009 Ethnic & Gender Immune Response Differences
Won-Suk Chung Stainier 2009 Induction of Pancreatic Beta Cells in Zebrafish
Jeff Mold McCune 2009 The Development of the Human Fetal Adaptive Immune System and Its Role in Promoting Immunological Tolerance
Alika Maunakea Costello 2008 A conserved role for intragenic DNA methylation in cell context-specific gene regulation
Elizabeth Co Fisher 2008 The immune paradox of human pregnancy: Fetal trophoblasts and maternal leukocytes
Sarah Elson Johnson 2008 Characterization of the She3-dependent RNA transport system in Candida albicans
Dustin Khiem Black 2008 The transcription factor MEF2C regulates B cell maturation, proliferation, and function
Angell Shieh (MSTP) Shannon 2008 Interrogating the roles of specific downstream effector pathways in the pathogenesis of hematopoietic malignancies initiated by oncogenic K-RasG12D
Larry Shiow (MSTP) Cyster 2008 The Regulation and Mechanism of Lymphocyte Egress
Zaman Mirzadeh (MSTP) Alavarez-Buylla 2008 Epithelial organization of the adult neural stem cell niche
Vernon Phan McCormick 2008  
Jennifer Lilla Werb 2008 The role of mast cells and plasma kallikrein in mammary gland development